S.T.A.L.K.E.R.: Shadow of Chernobyl is perfectly playable 'out of the box', it hasn't been "unplayable" since its release date 12 years ago. To significantly polish it up, you only need to apply one patch. To significantly improve the graphics and polish it up, you only need XpressTuning's Remaster Edition (Non-ENB).
I played the GoG version of the original SoC. Col. Petrenko(?) aka the Duty trader at Rostok was killed during a Mercenary attack. From that point on, I was not able to buy anything from the Duty store because there was no one there. I think important NPCs getting killed is still a problem. That could potentially be game-breaking and ruin a campaign.
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